Table of Contents
(Summary of 10 key academic outcomes of NMN in 2023):
1. NMN supplementation inhibits tumor growth and metastasis.
2. NMN supplementation can restore olfactory function
3. Oral NMN improves vascular health in middle-aged adults
4. High-dose NMN inhibits lung adenocarcinoma growth
5. Long-term NMN supplementation improves diabetes
6. NMN supplementation attenuates PM2.5 and other particulate matter-induced lung injury
7. NMN supplementation protects against viruses while reducing virus-mediated inflammation
8. Human Clinical Trials of NMN in China, Japan, and the U.S.: Oral NMN is Safe
9. Long-term NMN supplementation to prevent stroke-induced brain damage
10. NMN supplementation inhibits neoplastic tumorigenesis, metastasis.
11. Conclusion
12. BalanceGenics PURE NMN
NMN, β-nicotinamide mononucleotide, is a crucial precursor of the coenzyme NAD+ required by the human body. NAD+ serves as an essential ingredient in the cellular DNA repair system and acts as a key liaison between the cell nucleus and the mitochondria responsible for energy synthesis.
However, NAD+ levels decline rapidly with age. Therefore, taking NMN that can elevate NAD+ levels and restore cellular energy levels and gene repair capabilities to a youthful state, thereby achieving the effect of delaying or even reversing aging.
This article will provide an overview of the latest developments in NMN scientific research in 2023, offering a more precise understanding of just how remarkable NMN truly is!
Summary of 10 key academic outcomes of NMN in 2023:
1. NMN supplementation inhibits tumor growth and metastasis.
In January 2023, a research team from Tsinghua University, China's No. 1 ranked university, published a study entitled "NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling" in the prestigious international journal Oncogene.
Source | nature.com
The study showed that NMN supplementation inhibited triple-negative breast cancer (TNBC) tumor growth. In addition, NMN significantly improved cancer survival and stopped cancer metastasis. The findings may hold promise for inhibiting the growth and spread of TNBC.
2. NMN supplementation can restore olfactory function
In February 2023, Prof. Vilhelm A. Bohr's team at the National Institute on Aging published a paper entitled "Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57 cells" in the journal Aging Cell. inflammation and DNA damage in C57BL/6J mice".
Source| onlinelibrary.wiley
According to the research, Olfactory dysfunction may be a more sensitive early biomarker of aging than memory and motor behavioral deficits, and NAD+ supplementation restores olfaction and extends lifespan in aging mice.
Nicotinamide mononucleotide (NMN) is a physiologically circulating nicotinamide adenine dinucleotide (NAD+) precursor, and supplementation with NMN increased cellular levels of NAD+.
NAD+ supplementation extends lifespan and restores olfactory function in aged mice
Image source | onlinelibrary.wiley
3. Oral NMN improves vascular health in middle-aged adults
In February 2023, a Japanese team from the laboratories of DHC Corporation published a paper entitled "Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long- term nicotinamide mononucleotide supplementation: termnicotinamide mononucleotide supplementation: a randomized, double-blind, placebo.controlled trial".
Source | nature.com
The 12-week randomized, double-blind, placebo-controlled, parallel-group clinical trial demonstrated that long-term supplementation with 250 mg/day of NMN was well tolerated and did not cause adverse events. NMN supplementation can improve vascular health in middle-aged adults, especially for those with high BMI or blood glucose levels.
4. High-dose NMN inhibits lung adenocarcinoma growth
In April 2023, the top medical journal Cancers published an online article entitled "High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway".
The results of the study showed that local application of high-dose NMN strongly inhibited tumor growth and induced tumor iron death in lung adenocarcinoma cells. Under the application of high-dose NMN, nicotinamide (NAM) produced by excessive metabolism inhibited AMPK phosphorylation by targeting SIRT1, triggered the iron death process through the ACC activation pathway, and inhibited lung adenocarcinoma growth.
Principle of action of high-dose NMN in regulating iron death in lung adenocarcinoma cells
Image source|pubmed.ncbi.nmn.nih
5. Long-term NMN supplementation improves diabetes
In May 2023, Clinical Nutrition, the official journal of the European Society of Clinical Nutrition and Metabolism (ESPEN), published an online article entitled "Nicotinamide mononucleotide (NMN) intake increases plasma NMN and insulin levels in healthy subjects". NMN intake increases plasma NMN and insulin levels in healthy subjects".
Source| clinicalnutritionespen.com
The study found that postprandial serum insulin levels increased with NMN intake, and that long-term intake of NMN may increase the duration of postprandial insulin secretion, which may effectively improve diabetes disease states.
6. NMN supplementation attenuates PM2.5 and other particulate matter-induced lung injury
In July 2023, Environmental Health Perspectives, a journal of the National Institute of Environmental Health Sciences, published an article titled "Assessing the Effects of Nicotinamide Mononucleotide Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Subchronically Exposed to Ambient Particulate Matter".
The study demonstrated that NMN supplementation can have a restorative effect on PM2.5 and other particulate matter-induced lung damage by regulating immune function and lipid metabolism. These new findings provide new ideas for the application of dietary supplements such as NMN in effectively intervening in lung injury, and offer new insights into how to protect human health under unfavorable environmental stimuli.
7. NMN supplementation protects against viruses while reducing virus-mediated inflammation
In July 2023, Scientific Reports published an online article titled "Nicotinamide mononucleotide (NMN) alleviates the poly(I:C)-induced inflammatory response in human primary cell cultures".
The study found that NMN reduced the expression of inflammatory response-associated factors (including IL-6 and PARP family members) induced by related substances, revealing the ability of NMN supplementation to attenuate virus-mediated inflammation and reduce viral replication.
IL-6 expression levels in HPMECs (A) and HCAECs (B) lung cells treated with different doses of NMN
Image source | pubmed.ncbi.nmn.nih.gov
8. Human Clinical Trials of NMN in China, Japan, and the U.S.: Oral NMN is Safe
In August 2023, Advances in Nutrition published a review entitled "The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update". The article summarizes the progress of human clinical trials of NMN and NMN/NAD+ biology conducted in China, Japan and the United States.
From these human clinical trials, it can be seen that oral doses of NMN ranging from 100mg/d to 2000mg/d are safe with no significant side effects found! With 250mg/d being the most commonly used dose.In addition, these human clinical trials have demonstrated that NMN supplementation can significantly increase NAD+ levels in blood, bone, and muscle, thus playing an important role in human health.
Changes in NAD+ levels during aging (a), methods to restore NAD+ levels
(b) Image source | advances.nutrition.org
9. Long-term NMN supplementation to prevent stroke-induced brain damage
In September 2023, Neuron, one of the most influential journals in the field of neuroscience, published online a research paper entitled "NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis".
Source | www.cell.com/neuron
The study illustrates the important role of NAD+ in blood-brain barrier-associated vascular cell senescence and reveals a new mechanism for NAD+ to reverse aging-associated blood-brain barrier function.
The results show that NMN supplementation can help mice prevent BBB dysfunction and reduce stroke-induced brain damage due to BBB dysfunction.
10. NMN supplementation inhibits neoplastic tumorigenesis, metastasis.
In November 2023, a paper entitled was published in the prestigious tumor immunology journal, J Immunother Cancer." Tumor cell-induced macrophage senescence plays a pivotal role in tumor initiation" followed by stable growth in immunocompetent condition".
Source | jitc.bmj.com
The study found that senescence of tumor-associated macrophages leads to sluggish T-cell responses, and that NMN supplementation inhibits macrophage senescence and preserves T-cell function. In addition, NMN supplementation inhibited neoplastic tumorigenesis, including inhibition of metastasis, in a mouse model and could be applied after resection of the primary tumor.
11. Conclusion
The core mechanism of human aging is damaged cell genes and decreased mitochondrial energy production, leading to premature apoptosis or decreased cell viability, causing an increased incidence of cancer, diabetes, cardiovascular disease, dementia, and many other diseases due to human aging.
In 2023, through the continuous efforts and research of scientists, the veil of NMN was gradually unveiled and the magical effects of NMN were understood. In the era of increasing aging, how to scientifically and effectively maintain the health of the body and delay aging is an urgent problem to be faced and solved. Our anti-aging product, Pure NMN that contains 250 mg of NMN per Capsule, will become your powerful ally to bring about a longer and heathier lifespan!
12. BalanceGenics PURE NMN
Balancegenics' Pure NMN is a supplement that utilizes golden standard high-purity (>99.5%) NMN (nicotinamide mononucleotide), a powerful longevity ingredient that can boosts NAD, reduces physical and neurological decline.
Key Features:
- Made in USA.
- This Uthever® NMN from BalanceGenics is the gold standard for purity.
- Tested independently by third-party laboratories to confirm high purity and low heavy metal content.
- Next-generation stabilization technology for the NMN, with the crystal arrangement optimized to ensure long-term stability.
- The ultimate longevity elixir crafted with the most potent, pharmaceutical-grade NMN available.
- Recommended to take Balancegenics' Pure NMN in combination with Balancegenics’ 12 Rev-Time product for best results
- 120 CAPSULES
- 250mg/Capsule
- 30,000mg Per Bottle
For more information, please see BalanceGenics Product page：
The PURE NMN from BalanceGenics is the Gold Standard for Purity.
References:
- Yi Jiang, Zhongrui Luo, et al., NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling. PMID: 36690678,DOI: 10.1038/s41388-023-02592-y
- Xiuli Dan, Ross A., et al., Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice. https://doi.org/10.1111/acel.13793
- Katayoshi T, Uehata S, Nakashima N, et al. Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial. Sci Rep. 2023;13(1):2786. Published 2023 Feb 16. doi:10.1038/s41598-023-29787-3
- Zhang, Mingjiong et al. “High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway.” Cancers vol. 15,9 2427. 23 Apr. 2023, doi:10.3390/cancers15092427
- Takuya Yamane, Momoko Imai, Takeshi Bamba, et al. Nicotinamide mononucleotide (NMN) intake increases plasma NMN and insulin levels in healthy subjects. Clin Nutr ESPEN. 2023 Aug:56:83-86. doi: 10.1016/j.clnesp.2023.04.031. Epub 2023 May 5. PMID: 37344088.
- Rui Zhang, et al. “Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Subchronically Exposed to Ambient Particulate Matter.” Environmental health perspectives vol. 131,7 (2023): 77006. doi:10.1289/EHP12259
- Hitomi Sano, Anton Kratz ,Taiko Nishino, et al. Nicotinamide mononucleotide (NMN) alleviates the poly(I:C)-induced inflammatory response in human primary cell cultures. Sci Rep. 2023 Jul 20;13(1):11765. doi: 10.1038/s41598-023-38762-x. PMID: 37474783.
- Qin Song , Xiaofeng Zhou , Kexin Xu , et. al. The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update. Adv Nutr. 2023 Aug 22:S2161-8313(23)01359-5. doi: 10.1016/j.advnut.2023.08.008. Online ahead of print. PMID: 37619764.
- Rui Zhan, Xia Meng , Dongping Tian , et al. NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. Neuron. 2023 Aug 29:S0896-6273(23)00622-0. doi: 10.1016/j.neuron.2023.08.010. Online ahead of print. PMID: 37683629.
- Haruka Wada , Ryo Otsuka , Wilfred T V Germeraad , et. al. Tumor cell-induced macrophage senescence plays a pivotal role in tumor initiation followed by stable growth in immunocompetent condition. J Immunother Cancer. 2023 Nov;11(11):e006677. doi: 10.1136/jitc-2023-006677. PMID: 37963635.
